Synergistic Benefits on Combining Injectable Platelet-Rich Fibrin and Bone Graft Porous Particulate Materials

The main aim of this study was to perform an integrative review on the enhanced bone healing by combining a flowable (injectable) platelet-rich fibrin (PRF) and graft porous materials. A bibliographical search carried out several databases (PubMed, Embase, Cochrane, Scopus, Web Science) for relevant studies combined effect substitutes healing. chemical, biologic, physical properties PRF with biomaterials were discussed in review. repair different defects reported such as alveolar cleft reconstruction, sinus floor elevation, socket preservation, jaw defects, impacted teeth. Regarding evaluating results showed potential benefits enhance formation when mixed autogenous graft. Two preservation found growth substitutes, although one similar or without substitutes. Also, addition demineralized bovine mineral improved defects. No synergistic associated particulate elevation. combination materials revealed significant outcomes compared solely use In applied comparison PRF. On reconstruction larger can be low resorption rate material maintain biological mechanical stability into defect. fact, appear exhibit during tissue